Topic:

Antibiotic resistance

Abstract No.:

ISE.009

Title:

Multi drug resistance Acinetobacter baumannii and non- baumannii in Iran; a prospective study in several hospitals

Author(s):

F. Abbasi¹, M. Khalili-Azad², D. Yadegarynia³, S. Asadi², L. Gachkar², S. Kazemi²; ¹Bushehr University of Medical sciences, infectious diseases, Bushehr/IR, ²Shahid Beheshti Medical University, Infectious Diseases and Tropical Medicine Research Center, Tehran/IR, ³Shaheed Beheshti Medical University, Tehran/IR

Abstract:

Background: Acinetobacter species have become increasingly resistant to antibiotics over the past several years and currently present a significant challenge in treating these infections. They are important cause of nosocomial infections.
Methods: In a prospective study we evaluated 100 positive cultures of Acinetobacter from 100 patients in different wards of seven tertiary care hospitals in Tehran, Iran in a 6 months period. PCR was used to determine the species of Acinetobacter. E-test and Disk diffusion method was used to determine the resistance of isolated Acinetobacter baumannii and non-baumannii. Antimicrobial sensitivity to following antibiotics was analyzed: ceftazidime, cefepime, amikacin, imipenem, piperacillin-tazobactam, tigecycline and colistin.
Results: In our study 89% of isolated Acinetobacter was baumannii and 11% non- baumannii. Of the smples, 70% were isolated from male and 30% from female patients. The most infected wards were intensive care and burn units with a high prevalence of pneumonia and wound infection due to Acinetobacter. The most frequent sites of infection were respiratory tract (38%), wound (29%), tip of catheter (14%), urine (8%), blood (4%), cerebrospinal fluid (4%), pleural fluid (2%) and brain abscess (1%). Acinetobacter was resistant to amikacin in 100%, ceftazidime in 100%, cefepime in 94.5%, piperacillin-tazobactam in 83% and imipenem in 64% of the samples. Sensitivity to colistin and tigecycline was 100% and 74.5% respectively.
Conclusion: In our study, the most common site of infection with acintobacter was respiratory tract, followed by wound and tip of catheter. The organism was resistant to most of the widely used antibiotics while a considerable sesitivity was observed to colistin and tigecyclin.