Topic:

Virology and viral infections (non-hiV)

Abstract No.:

ISE.069

Title:

Virologic Indexes of Hepatitis B and risk factors in pregnant women in  Salmas City, West-Azerbaijan of Iran

Author(s):

F. Fayyaz Jahani¹, E. Ahmadnezhad², R. Ghahramanzadeh³, M. Hamzezadeh³, K. Ashrafi⁴, M. Chavoshi⁵, M. Souldozi³; ¹Urmia university of medical sciences, Infectious Disease, Tehran/IR, ²Inistitute of public Health,Tehran University of medical sceinces, public Health, Tehran/IR, ³Urmia university of medical sciences, Infectious Disease, Urmia/IR, ⁴Urmia university of medical sciences, Infectious Disease, Salmas/IR, ⁵Urmia university of medical sciences, public Health, Salmas/IR

Abstract:

Background: Countries in Middle East have the moderate prevalence rate of hepatitis B (2-7%) and the risk of hepatitis B occurrence is 20-60% during life. The most common cause of chronic hepatitis in Iran is HBV (70-80%). This study was conducted in Salmas to determine virologic index of hepatitis B and its risk factors in pregnant women.
Methods: It was a cross-sectional study that 600 pregnant women, who were in first trimester, were selected through lot quality assurance sampling. A face-to-face interview was conducted for data gathering and then serum was separated by centrifuge and after packaging and numbering, was transported to a freezer and stored at -20°C until examination. Commercial kits and ELISA test examined Blood samples. The data provided in questionnaires and test results were analyzed using STATA v.₁₁.
Results: The prevalence of Hepatitis B was 4.5%. The prevalence of isolated HBcAb was 7.8%, however, isolated HBsAb was reported in 10.6%. HBcAb and HBsAb were positive in 11.9%. Of 42 hepatitis B subjects, 4 were HBeAg positive, however, 38 were HBeAg negative and HBeAb positive. The most common risk factor were the family history and surgery (OR=3.5 and OR=2.4 respectively)
Conclusion: Serologic prevalence of hepatitis B in Salmas among pregnant women revealed that this city is among the moderate-prevalence cities in Iran. We have to put a special emphasis on the importance of hepatitis B screening tests during pregnancy in order for planning vaccination programs and prevention of pregnancy and labor complications induced by this disease.