Topic:

Parasitology and parasitic infections

Abstract No.:

ISE.255

Title:

Serological profile of pregnant women against to Toxoplasma gondii in University hospital: retrospective study

Author(s):

N. Dogan; Osmangazi University medical faculty, Parasitology, Eskisehir/TR

Abstract:

Background: The aim of this study was to determine last seven years the seropositivity of Toxoplasma gondii in in pregnant women admitted to the outpatient clinic of Eskisehir Osmangazi University Medical Faculty Training and Research Hospital, Department of Obstetrics and Gynecology.
Methods: A retrospective cross sectional study was performed in a University hospital in microbiology laboratuary from Eskisehir, Turkey between January 2005 and January 2012. Total 4107 pregnant women with mean (SD) age 26 years screened microbiology department. Data were extracted for the presence or absence of anti-T gondii IgG and IgM antibodies. Specific IgG antibodies against T gondii were detected Enzyme Immuno Assay Test in sera (Vidas/Biomerieux Laboratories, France anti IgG-IgM and Avidity tests).
Results: A total of 4107 IgM and  3676 IgG anti toxo antibodes was performed in pregnant women at seven years. Seropozitivity rates found over the years an average of 20% IgG and 0.08 % IgMToxoplasmosis seropositivity rate was decreased in recent years in our area.
Conclusion: The prevalence of mother-to-child transmitted infections depends on the origin of pregnant women. Knowledge of these differences may lead to improved control these diseases. In order to avoid congenital toxoplasmosis and the possible complications of pregnancy Toxoplasma gondii surveilance studies should be planned. Detection of specific IgG, IgM and IgA antibodies by enzyme immunoassay (EIA) tests are not always sufficient in the diagnosis of early and late Toxoplasma gondii infection during pregnancy. Specific IgG avidity test should be used to detect primary infection. Borderline and high IgM levels showed a good correlation with the IgG avidity results.