Topic:

Virology and viral infections (non-hiV)

Abstract No.:

ISE.473

Title:

Prevalence of type II diabetes mellitus in hepatitis C virus infection in western Algeria

Author(s):

A. Benabdellah; CHU.Oran, infectiuos diseases, Oran/DZ

Abstract:

Background: Hepatitis C virus infection is emerging as a metabolic disease and diabetes mellitus as a risk factor.Type II diabetes mellitus (DM) has been shown as more common in patients with hepatitis C virus infection (HCV). Similar data from Algeria is not available.
Methods: This 7-year retrospective study from 2005 to 2011  included consecutive Algerian patients with HCV to detect the DM. In all patients, the presence of DM, duration of DM, probable duration of HCV, genotype of HCV, presence of steatosis and presence of cirrhosis were noted.
Results: A total of 140 patients with HCV were analysed: mean age = 45.9 +/- 9.8 years; 57% of patients were female;genotype distribution: genotype 2 in 58%, genotype 1 in 49% ,genotype 3 in 2% and genotype 4 in 1% of patients. Cirrhosis and steatosis were present in 2(1.4 %) patients. DM was present in 4 (2.5%) patients
Conclusion: The risk factors associated with the development of DM in the general population cannot alone account for the high prevalence of DM obtained in chronic HCV  infection. In the absence of liver fibrosis and steatosis, the improvement in glycemic control obtained in SVR patients may imply direct involvement of HCV in the development of DM.