Updates of the WHO Classification of Brain and Pituitary Tumors

September 19-20, 2019

Available Credits 16 CME, 16 SAM

Course Description

For the first time, the 2016 WHO classification of central nervous system (CNS) tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. These new updates will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors. General pathologists, in particular, must become familiar with changes in diagnostic criteria and utilize them in their practice improvement strategies. The WHO classification of pituitary adenomas was revised in 2017 and includes (1) a recommendation for the assessment of pituitary transcription factors with focus on adenohypophysial-cell lineage and (2) replacement of "atypical adenoma" with "high risk adenoma" based on tumor proliferation markers and other clinical parameters (such as invasion) to predict aggressiveness. This course will illustrate and reinforce these important updates.

Course Objectives

• Apply the cIMPACT-NOW and 2016 updates to the WHO classification for the diagnosis of adult diffuse gliomas
• Utilize morphologic and molecular diagnostic techniques to diagnose pediatric brain tumors
• Explain the role of integrated molecular and histological criteria in the classification of other CNS tumors including dural and embryonal neoplasms
• Summarize the changes in neuroendocrine and non-neuroendocrine pituitary tumor classification
• Apply the 2017 update to the WHO classification of pituitary tumors to the diagnosis of sellar region tumors

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